![]() Recently, the better synthetic availability of sulfoximines (as exemplified by roniciclib 4), sulfonimidamides, and sulfonimidates has led to the increased interest in their possible application in drug design. As a consequence, pharmaceutical and agrochemical industry manifest an increasing interest in these chemicals, part of which have been marketed as drugs, like esomeprazole 2 and its various derivatives used as antiulcer drugs or modafinil 3 ( Figure 2). (8) Synthetic sulfinyl compounds often exhibit a significant biological activity. (5−7)Ĭhiral organosulfur derivatives are found in natural systems such as methionine sulfoxide, S-adenosyl methionine, allicin, or leinamycin 1 ( Figure 2). Three important reviews published in the last five years deal with this emerging application of chiral sulfoxides and their analogues in asymmetric catalysis. (3,4) Nonracemic sulfinyl compounds are also used in catalytic stereoselective reactions, both as ligands for transition metals and as chiral organocatalysts. (2) Recent reviews show the utility of various sulfur derivatives in organic synthesis. As an example, tert-butane sulfinamide introduced by Ellman and co-workers finds numerous applications in the synthesis of enantiomerically pure amines and their derivatives, in many cases exhibiting significant biological activity. ![]() It is relatively easy to introduce and remove, configurationally stable, and capable of high asymmetric induction. The sulfinyl group is considered as a valuable chiral auxiliary, used in the stereoselective preparation of variety of useful chiral compounds. Symbols, abbreviations, or full names for units of length,Īrea, mass, pressure, and other types.These derivatives deserve attention due to their importance in modern synthetic, medicinal, and agricultural chemistry. ![]() You can find metric conversion tables for SI units, as wellĪs English units, currency, and other data. It is the pressure resulting from a force of one pound-force applied to an area of one square inch.Ĭonversion calculator for all types of measurement units. The pound per square inch or, more accurately, pound-force per square inch (symbol: psi or lbf/in² or lbf/in²) is a unit of pressure or of stress based on avoirdupois units. Psf to psi, or enter any two units below: Enter two units to convert From: ![]() You can do the reverse unit conversion from ![]()
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